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Image Search Results
Journal: iScience
Article Title: Supinoxin blocks small cell lung cancer progression by inhibiting mitochondrial respiration through DDX5
doi: 10.1016/j.isci.2025.112219
Figure Lengend Snippet: RNA-seq analysis reveals downregulated mitochondrial function following Supinoxin treatment (A) A Venn diagram illustrating the total number of transcripts upregulated and downregulated following Supinoxin treatment and DDX5 knockdown. It was generated using the Venn diagram package in R Studio (version 2023.12.0). (B) A heatmap was generated to display the differential expression patterns of transcripts affected by Supinoxin treatment. Red indicates upregulation, while blue represents downregulation, based on Log 2 FC values. Z scores were applied to enhance gene clustering in response to Supinoxin treatment. Expression intensity values were calculated using RStudio to analyze gene expression levels. (C) Volcano plot depicting differentially expressed genes (DEGs) between H69AR cells with or without Supinoxin treatment. The plot was generated from the p values (∗<0.05, not significant) and Log 2 FC values (>1; <−1). The colored dots indicate genes with significant expression differences. Blue dots represent genes with significant differences based on p value alone, green dots on Log 2 FC alone, red dots represent genes with significant differences based on both p value and Log 2 FC, and gray dots are not significant in either term.
Article Snippet: The expression patterns of selected genes across treated and untreated samples were then illustrated in a
Techniques: RNA Sequencing, Knockdown, Generated, Quantitative Proteomics, Expressing, Gene Expression